Isistimu yokuqoqwa kwe-plasma ehlakaniphile isebenza ngaphakathi kwesistimu evaliwe, isebenzisa iphampu yegazi ukuqoqa igazi eliphelele enkomishini ye-centrifuge. Ngokusebenzisa ukuminyana okuhlukene kwezingxenye zegazi, inkomishi ye-centrifuge ijikeleza ngesivinini esikhulu ukuze ihlukanise igazi, ikhiqize i-plasma yekhwalithi ephezulu kuyilapho iqinisekisa ukuthi ezinye izingxenye zegazi azilimele futhi zibuyiselwa ngokuphephile kumnikeli.
Ihlangene, ingasindi, futhi ihambeka kalula, ilungele iziteshi zeplasma ezivaleleke emkhathini kanye nokuqoqwa kweselula. Ukulawulwa okunembile kwama-anticoagulants kukhulisa isivuno se-plasma esebenzayo. Umklamo wokukala obekwe ngemuva uqinisekisa ukuqoqwa kwe-plasma okunembile, futhi ukuqashelwa okuzenzakalelayo kwezikhwama ze-anticoagulant kuvimbela ubungozi bokubekwa kwesikhwama okungalungile. Isistimu iphinde ibe nama-alamu asezingeni eliphakeme alalelwayo ukuze kuqinisekiswe ukuphepha kuyo yonke inqubo.
I-ASFA - izinkomba eziphakanyisiwe zokushintshaniswa kwe-plasma zifaka i-toxicosis, i-hemolytic uremic syndrome, i-Goodpasture syndrome, i-systemic lupus erythematosus, i-Guillain-barr syndrome, i-myasthenia gravis, i-macroglobulinemia, i-hypercholesterolemia yomndeni, i-thrombotic thrombocytopenic purpura, i-autoimmune hemolytic anemia, njll. odokotela kanye ne-ASFA imihlahlandlela.